Most people driving to Irymple come from Melbourne via the Western Freeway and then the Calder Highway through Bendigo and up through the Mallee, a drive of roughly 5.5 to 6 hours that crosses from the green coastal ranges into progressively flatter and more arid country as you head north. It's a drive that changes character about halfway through and the last two hours through the red-grey Mallee scrub is genuinely striking if you're paying attention to what's outside the car rather than just the kilometres remaining.
From Adelaide the drive comes in from the west across the South Australian border on the Sturt Highway, about 4 hours depending on where you're starting from, and that approach through Renmark and along the Murray corridor is arguably more interesting than the Victorian route and arrives with the river alongside you for the last stretch. Sydney travellers generally come down through Broken Hill and across the outback on the Silver City Highway which is a proper outback drive and not something to attempt without checking road conditions and carrying water.
Mildura Airport handles flights from Melbourne and Sydney with several services daily, and the drive from the airport to the motel is about 15 minutes - hire cars are available at the terminal and for anything other than a one-night stop it's worth having your own vehicle given how spread out the region is and how limited public transport becomes outside the city itself.
Getting around once you're at the motel is essentially car-dependent, which is simply the reality of regional outback Victoria and not a criticism of anything in particular. Irymple and Mildura together are navigable but the distances between things are real, public transport between the two is limited and infrequent, and the wine region and river destinations that make the area worth visiting are not accessible any other way. If you arrived without a car and are staying more than a night, sort out a hire from Mildura before you need it rather than after.
Parking at the motel is large, flat and completely without stress - caravans and trailers park without drama, work vehicles with equipment on the back are fine, and there's no situation where you're circling at the end of a long drive trying to work out where to put the car. For travellers coming off the highway that specific absence of parking anxiety is a small but genuinely appreciated thing.